Synexpression groups in eukaryotes
- 1 December 1999
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 402 (6761), 483-487
- https://doi.org/10.1038/990025
Abstract
In 1960, Jacob and Monod described the bacterial operon, a cluster of functionally interacting genes whose expression is tightly coordinated. Global expression analysis has shown that the highly coordinate expression of genes functioning in common processes is also a widespread phenomenon in eukaryotes. These sets of co-regulated genes, or 'synexpression groups', show a striking parallel to the operon, and may be a key determinant facilitating evolutionary change leading to animal diversity.Keywords
This publication has 39 references indexed in Scilit:
- Notch Signaling: Cell Fate Control and Signal Integration in DevelopmentScience, 1999
- The Transcriptional Program in the Response of Human Fibroblasts to SerumScience, 1999
- Exploring the new world of the genome with DNA microarraysNature Genetics, 1999
- Options available — from start to finish — for obtaining expression data by microarrayNature Genetics, 1999
- The Transcriptional Program of Sporulation in Budding YeastScience, 1998
- Gene‐expression screens in vertebrate embryos: more than meets the eyeGenes and Function, 1997
- The Complete Genome Sequence of Escherichia coli K-12Science, 1997
- Partnership between DPC4 and SMAD proteins in TGF-β signalling pathwaysNature, 1996
- Developmental Integration and the Evolution of PleiotropyAmerican Zoologist, 1996
- The MAP kinase cascade is essential for diverse signal transduction pathwaysTrends in Biochemical Sciences, 1993