Respiratory Complications in Children Hospitalized with Varicella
- 30 May 2013
- book chapter
- other
- Published by Springer Science and Business Media LLC in Advances in Experimental Medicine and Biology
- Vol. 788, 97-102
- https://doi.org/10.1007/978-94-007-6627-3_15
Abstract
The aim of the study was to retrospectively determine the incidence and clinical course of varicella-related respiratory complications in children during the 6-year period 2005–2010. We attempted to identify the predisposing factors and outcome of such complications. Clinical records of 237 children treated in an academic hospital of the Medical University in Wroclaw, Poland were reviewed, taking into consideration the reason for referral to the hospital, duration of hospitalization, and diagnosis. There were 28 (11.8 %) children (mean age 2.8 ± 2.8 years) in the cohort hospitalized with varicella-related respiratory complications. The infants younger than 1 year predominated (9/28). None of the children were previously immunized against varicella. Admission occurred 5.0 ± 2.8 days after the first symptoms of varicella. The source of infection was an older sibling in 13/28 cases. The mean duration of hospitalization was 5.4 ± 2.0 days. The main symptoms were fever (20/28), cough (26/28), tachypnea (11/28), and dyspnea (7/28). Chest X-ray was performed in eight children, confirming pneumonia in six cases. Based on blood gases, chest X-ray, and clinical symptoms, pneumonia was diagnosed in 15/28 and acute bronchitis in 8/28 children. Intravenous antiviral therapy with acyclovir was administered in 16/28 and antibiotics in 14/28 children. In two cases, oxygen therapy was required and one child presented respiratory failure treated in the Intensive Care Unit. We conclude that respiratory tract involvement in the course of varicella infection in children is relatively common. Age less than 1 and an infected older sibling seem major risk factors for respiratory complications.This publication has 13 references indexed in Scilit:
- Long Term Sequelae from Childhood Pneumonia; Systematic Review and Meta-AnalysisPLOS ONE, 2012
- How frequent is varicella-associated pneumonia in children?European Journal of Clinical Microbiology & Infectious Diseases, 2010
- Varicella-zoster virus pneumonia in an adult population: Has mortality decreased?Scandinavian Journal of Infectious Diseases, 2009
- Epidemiology and etiology of childhood pneumoniaBulletin of the World Health Organization, 2008
- Severe complications of chickenpox in hospitalised children in the UK and IrelandArchives of Disease in Childhood, 2007
- Varicella pneumonia in adults: 13 years' experience with review of literatureAnnals of Thoracic Medicine, 2007
- Hospitalizaciones por varicela en el Hospital Infantil La Fe (Valencia 2001-2004)Anales de Pediatría, 2005
- Does This Patient Have Community-Acquired Pneumonia?JAMA, 1997
- The Epidemiology of Varicella and Its ComplicationsThe Journal of Infectious Diseases, 1995
- Modification of Chicken Pox in Family Contacts by Administration of Gamma GlobulinThe New England Journal of Medicine, 1962