A Single Amino Acid of the Human Immunodeficiency Virus Type 2 Capsid Affects Its Replication in the Presence of Cynomolgus Monkey and Human TRIM5αs
Open Access
- 1 July 2007
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 81 (13), 7280-7285
- https://doi.org/10.1128/jvi.00406-07
Abstract
Human immunodeficiency virus type 2 (HIV-2) strains vary widely in their abilities to grow in Old World monkey (OWM) cells such as those of cynomolgus monkeys (CM). We evaluated eight HIV-2 isolates for their sensitivities to CM TRIM5α, an anti-HIV factor in OWM cells. We found that different HIV-2 isolates showed differences in their sensitivities to CM TRIM5α. Sequence analysis showed that TRIM5α-sensitive viruses had proline at the 120th position of the capsid protein (CA), whereas TRIM5α-resistant viruses had either alanine or glutamine. Mutagenesis studies indicated that the single amino acid at the 120th position indeed affected the sensitivity of the virus to CM TRIM5α.This publication has 38 references indexed in Scilit:
- All Three Variable Regions of the TRIM5α B30.2 Domain Can Contribute to the Specificity of Retrovirus RestrictionJournal of Virology, 2006
- Differential Restriction of Human Immunodeficiency Virus Type 2 and Simian Immunodeficiency Virus SIVmac by TRIM5α AllelesJournal of Virology, 2005
- A Specific Region of 37 Amino Acid Residues in the SPRY (B30.2) Domain of African Green Monkey TRIM5α Determines Species-Specific Restriction of Simian Immunodeficiency Virus SIVmac InfectionJournal of Virology, 2005
- High-resolution structure of a retroviral capsid hexameric amino-terminal domainNature, 2004
- The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeysNature, 2004
- Increased Virus Replication and Virulence after Serial Passage of Human Immunodeficiency Virus Type 2 in BaboonsJournal of Virology, 2003
- Equal Plasma Viral Loads Predict a Similar Rate of CD4+T Cell Decline in Human Immunodeficiency Virus (HIV) Type 1– and HIV‐2–Infected Individuals from Senegal, West AfricaThe Journal of Infectious Diseases, 2002
- AIDS as a Zoonosis: Scientific and Public Health ImplicationsScience, 2000
- Short Communication: Transient Virus Infection and Pathogenesis of a New HIV Type 2 Isolate, UC12, in BaboonsAIDS Research and Human Retroviruses, 1998
- SIMULTANEOUS ISOLATION OF HIV-1 AND HIV-2 FROM AN AIDS PATIENTThe Lancet, 1988