Arc-dependent synapse-specific homeostatic plasticity
- 27 December 2010
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 108 (2), 816-821
- https://doi.org/10.1073/pnas.1017914108
Abstract
Both theoretical and experimental research has indicated that the synaptic strength between neurons in a network needs to be properly fine-tuned and controlled by homeostatic mechanisms to ensure proper network function. One such mechanism that has been extensively characterized is synaptic homeostatic plasticity or global synaptic scaling. This mechanism refers to the bidirectional ability of all synapses impinging on a neuron to actively compensate for changes in the neuron's overall excitability. Here, using a combination of electrophysiological, two-photon glutamate uncaging and imaging methods, we show that mature individual synapses, independent of neighboring synapses, have the ability to autonomously sense their level of activity and actively compensate for it in a homeostatic-like fashion. This synapse-specific homeostatic plasticity, similar to global synaptic plasticity, requires the immediate early gene Arc. Together, our results document an extra level of regulation of synaptic function that bears important computational consequences on information storage in the brain.Keywords
This publication has 44 references indexed in Scilit:
- Stabilization of Ca 2+ -permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylationProceedings of the National Academy of Sciences of the United States of America, 2009
- AMPA Receptor Subunits Get Their Share of the PieNeuron, 2009
- Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic ApproachNeuron, 2009
- The Self-Tuning Neuron: Synaptic Scaling of Excitatory SynapsesCell, 2008
- Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network ReverberationNeuron, 2008
- Activity-Dependent Regulation of Synaptic AMPA Receptor Composition and Abundance by β3 IntegrinsNeuron, 2008
- Developmental presence and disappearance of postsynaptically silent synapses on dendritic spines of rat layer 2/3 pyramidal neuronsThe Journal of Physiology, 2008
- Rapid Synaptic Scaling Induced by Changes in Postsynaptic FiringNeuron, 2008
- The Cell Biology of Synaptic Plasticity: AMPA Receptor TraffickingAnnual Review of Cell and Developmental Biology, 2007
- Long-Term Potentiation in the Hippocampal CA1 Region Does Not Require Insertion and Activation of GluR2-Lacking AMPA ReceptorsJournal of Neurophysiology, 2007