TOR signaling in plants: conservation and innovation
- 1 July 2018
- journal article
- research article
- Published by The Company of Biologists in Development
- Vol. 145 (13)
- https://doi.org/10.1242/dev.160887
Abstract
Target of rapamycin (TOR) is an evolutionarily conserved protein kinase that plays a central role in both plants and animals, despite their distinct developmental programs and survival strategies. Indeed, TOR integrates nutrient, energy, hormone, growth factor and environmental inputs to control proliferation, growth and metabolism in diverse multicellular organisms. Here, we compare the molecular composition, upstream regulators and downstream signaling relays of TOR complexes in plants and animals. We also explore and discuss the pivotal functions of TOR signaling in basic cellular processes, such as translation, cell division and stem/progenitor cell regulation during plant development.Keywords
Funding Information
- National Institute of General Medical Sciences (R01 GM060493, R01 GM070567)
This publication has 117 references indexed in Scilit:
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1Cell, 2012
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEBThe EMBO Journal, 2012
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP PathwayCell, 2011
- Viral factor TAV recruits TOR/S6K1 signalling to activate reinitiation after long ORF translationThe EMBO Journal, 2011
- Arabidopsis S6 kinase mutants display chromosome instability and altered RBR1–E2F pathway activityThe EMBO Journal, 2010
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1Molecular Cell, 2010
- Structure of the Human mTOR Complex I and Its Implications for Rapamycin InhibitionMolecular Cell, 2010
- A new plant protein interacts with eIF3 and 60S to enhance virus-activated translation re-initiationThe EMBO Journal, 2009
- AMPK Phosphorylation of Raptor Mediates a Metabolic CheckpointMolecular Cell, 2008
- Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progressionCell, 1993