A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture
- 1 September 2012
- journal article
- webcast
- Published by American Physiological Society in American Journal of Physiology-Heart and Circulatory Physiology
- Vol. 303 (5), H619-H628
- https://doi.org/10.1152/ajpheart.00036.2012
Abstract
The role of microcalcifications (μCalcs) in the biomechanics of vulnerable plaque rupture is examined. Our laboratory previously proposed (Ref. 44 ), using a very limited tissue sample, that μCalcs embedded in the fibrous cap proper could significantly increase cap instability. This study has been greatly expanded. Ninety-two human coronary arteries containing 62 fibroatheroma were examined using high-resolution microcomputed tomography at 6.7-μm resolution and undecalcified histology with special emphasis on calcified particlesKeywords
This publication has 44 references indexed in Scilit:
- Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary ArteriesThe American Journal of Pathology, 2011
- Molecular Imaging Insights Into Early Inflammatory Stages of Arterial and Aortic Valve CalcificationCirculation Research, 2011
- Effects of intima stiffness and plaque morphology on peak cap stressBioMedical Engineering OnLine, 2011
- Carotid Atheroma Rupture Observed In Vivo and FSI-Predicted Stress Distribution Based on Pre-rupture ImagingAnnals of Biomedical Engineering, 2010
- 3D Critical Plaque Wall Stress Is a Better Predictor of Carotid Plaque Rupture Sites Than Flow Shear Stress: An In Vivo MRI-Based 3D FSI StudyJournal of Biomechanical Engineering, 2010
- Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerabilityAmerican Journal of Physiology-Heart and Circulatory Physiology, 2009
- Role of Computed Tomography Voxel Size in Detection and Discrimination of Calcium and Iron Deposits in Atherosclerotic Human Coronary Artery SpecimensJournal of Computer Assisted Tomography, 2009
- Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal DiseaseCirculation, 2009
- Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque ruptureAmerican Journal of Physiology-Heart and Circulatory Physiology, 2008
- A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous capsProceedings of the National Academy of Sciences of the United States of America, 2006