Quantitative Template for Subtyping Primary Progressive Aphasia
Open Access
- 1 December 2009
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 66 (12), 1545-1551
- https://doi.org/10.1001/archneurol.2009.288
Abstract
The classification of primary progressive aphasia (PPA) into subtypes has acquired new relevance in light of postmortem series and in vivo amyloid imaging showing that individual variants have different likelihoods of being caused by Alzheimer disease (AD) vs frontotemporal lobar degeneration (FTLD). The most frequent associations have been reported between the agrammatic variant (PPA-G) and FTLD with tauopathy (FTLD-T), the semantic variant (PPA-S) and FTLD with ubiquitin/TAR-DNA binding protein 43 proteinopathy (FTLD-TDP), and the logopenic variant (PPA-L) and AD.1-3Keywords
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