Risk Factors for Development of Tuberculosis after Isoniazid Chemoprophylaxis in Human Immunodeficiency Virus--Infected Patients
Open Access
- 1 February 2002
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 34 (3), 386-389
- https://doi.org/10.1086/324746
Abstract
The long-term benefit of isoniazid chemoprophylaxis in human immunodeficiency virus (HIV)–infected patients and risk factors for isoniazid failure were studied in 131 HIV-infected patients who received >9 months of isoniazid preventive therapy. During a median follow-up of 43 months, 8 patients developed tuberculosis (TB) (6%; 0.61 cases per 100 patient-years). Only the persistence of risk factors for exposure to TB was statistically associated with development of disease (relative hazard, 3.17; 95% confidence interval, 1.56–17; P < .001). Our data suggest reinfection as the main cause of TB after isoniazid prophylaxis.Keywords
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