Pulmonary Langerhans'-Cell Histiocytosis

Abstract

Pulmonary Langerhans'-cell histiocytosis forms part of a spectrum of diseases characterized by monoclonal proliferation and infiltration of organs by Langerhans' cells (Table 1).¹ Several organ systems may be involved in Langerhans'-cell histiocytosis, including the lungs, bone, skin, pituitary gland, liver, lymph nodes, and thyroid.² Lung involvement may occur either in isolation or as part of a multiorgan disease (Table 1). The term “pulmonary Langerhans'-cell histiocytosis” is used to refer to disease in adults that affects the lung, either in isolation or in addition to other organ systems.Localized forms of Langerhans'-cell histiocytosis have previously been referred to as eosinophilic granuloma, . . .