Serum Antibody Levels to Actinobacillus actinomycetemcomitans Predict the Risk for Coronary Heart Disease
- 1 April 2005
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 25 (4), 833-838
- https://doi.org/10.1161/01.atv.0000157982.69663.59
Abstract
Objective— The association between serum antibody levels to major periodontal pathogens and coronary heart disease (CHD) was analyzed in a prospective population-based study. Methods and Results— The population comprised 1023 men (aged 46 to 64 years) in the Kuopio Ischemic Heart Disease Study. The subjects with CHD at baseline (n=113) were more often seropositive for Porphyromonas gingivalis IgA (38.9% versus 28.5%, P =0.021) and IgG (60.2% versus 46.7%, P =0.007) than those without CHD. During the 10-year follow-up, 109 men free from CHD at baseline experienced an acute myocardial infarction or CHD death. The men with an end point were more often seropositive for Actinobacillus actinomycetemcomitans IgA (15.5% versus 10.2%, P =0.019) than those who remained healthy. In the highest tertile of A. actinomycetemcomitans IgA-antibodies compared with the lowest one, the relative risk (RR) for an end point adjusted for CHD risk factors was 2.0 (95% confidence interval [CI], 1.2 to 3.3). In the Porphyromonas gingivalis IgA-antibody tertiles, the highest RR of 2.1 (1.3 to 3.4) was observed in the second tertile. All antibody levels correlated positively with the carotid artery intima-media thickness. Conclusions— High-serum antibody levels to major periodontal pathogens are associated with subclinical, prevalent, and future incidence of CHD. Periodontal pathogens or host response against them may contribute to the pathogenesis of CHD.Keywords
This publication has 26 references indexed in Scilit:
- High serum antibody levels to Porphyromonas gingivalis predict myocardial infarctionEuropean Journal of Preventive Cardiology, 2004
- Antibodies to Periodontal Pathogens and Stroke RiskStroke, 2004
- Periodontitis decreases the antiatherogenic potency of high density lipoproteinJournal of Lipid Research, 2004
- Role for Periodontitis in the Progression of Lipid Deposition in an Animal ModelInfection and Immunity, 2003
- Relationship Between Periodontal Disease, Tooth Loss, and Carotid Artery PlaqueStroke, 2003
- Antibodies to Periodontal Pathogens Are Associated With Coronary Heart DiseaseArteriosclerosis, Thrombosis, and Vascular Biology, 2003
- Interactions of Porphyromonas gingivalis with Host Cells: Implications for Cardiovascular DiseasesThe Journal of Periodontology, 2003
- Multiserotype Enzyme-Linked Immunosorbent Assay as a Diagnostic Aid for Periodontitis in Large-Scale StudiesJournal of Clinical Microbiology, 2002
- Ethnicity and long-term outcome after an acute coronary eventAmerican Heart Journal, 1999
- Prevalence of carotid atherosclerosis and serum cholesterol levels in eastern Finland.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1988