HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
- 20 June 1996
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 381 (6584), 667-673
- https://doi.org/10.1038/381667a0
Abstract
The β-chemokines MIP-1α, MIP-1β and RANTES inhibit infection of CD4+ cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell–cell membrane fusion. CD4+ T cells from some HIV-1-exposed uninfected individuals cannot fuse with NSI HIV-1 strains and secrete high levels of β-chemokines. Expression of the β-chemokine receptor CC-CKR-5 in CD4+ , non-permissive human and non-human cells renders them susceptible to infection by NSI strains, and allows env-mediated membrane fusion. CC-CKR-5 is a second receptor for NSI primary viruses.Keywords
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