Liver Biopsy in Children
- 1 March 2015
- journal article
- practice guideline
- Published by Wiley in Journal of Pediatric Gastroenterology and Nutrition
- Vol. 60 (3), 408-420
- https://doi.org/10.1097/mpg.0000000000000632
Abstract
Liver biopsy (LB) is still the criterion standard procedure for obtaining liver tissue for histopathological examination and a valuable tool in the diagnosis, prognosis, and management of many parenchymal liver diseases. The aim of this position paper is to summarise the present practice of paediatric LB and make recommendations about its performance. Although histological evaluation of the liver is important in assessing prognosis and exploring treatment, noninvasive techniques (ie, imaging, laboratory markers) may replace use of liver histology. The indications for LB are changing as present knowledge of aetiologies, pathomechanism, and therapeutic options in paediatric liver disease is evolving. Adult and paediatric literature was reviewed to assess the existing clinical practice of LB with focus on the technique, indications, risk of complications, and contraindications in paediatrics. This position paper presents types of LB, indications, complications, contraindications, and an essential checklist for paediatric LB.Keywords
This publication has 132 references indexed in Scilit:
- Progressive Familial Intrahepatic Cholestasis Type 3Clinical Pediatrics, 2012
- Ethical aspects of participation in the Database of Genotypes and Phenotypes of the National Center for Biotechnology InformationCancer, 2012
- The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injuryJournal of Hepatology, 2011
- Design and Validation of the Biliary Atresia Research Consortium Histologic Assessment System for Cholestasis in InfancyClinical Gastroenterology and Hepatology, 2011
- Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection in children and adolescentsJournal of Hepatology, 2010
- Standardization of nomenclature and causality assessment in drug-induced liver injury: Summary of a clinical research workshopJournal of Hepatology, 2010
- Bile composition in Alagille Syndrome and PFIC patients having Partial External Biliary DiversionBMC Gastroenterology, 2008
- Acute liver failure: Summary of a workshopJournal of Hepatology, 2007
- Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: Summary statement of a First National Institutes of Health/Office of Rare Diseases conferenceThe Journal of Pediatrics, 2006
- Acute liver failure in children: The first 348 patients in the pediatric acute liver failure study groupThe Journal of Pediatrics, 2006