Botulinum Toxin Type A on Oral Health in Treating Sialorrhea in Children With Cerebral Palsy: A Randomized, Double-Blind, Placebo-Controlled Study
- 6 May 2011
- journal article
- research article
- Published by SAGE Publications in Journal of Child Neurology
- Vol. 26 (7), 838-843
- https://doi.org/10.1177/0883073810395391
Abstract
Intrasalivary gland injection of botulinum toxin type A is known to treat sialorrhea effectively in children with cerebral palsy. However, oral health may be compromised with escalating dose. In this randomized, double-blind, and placebo-controlled pilot trial, the authors aim to determine the therapeutic effect of low-dose, ultrasonography-controlled botulinum toxin type A injection to bilateral parotid and submandibular glands on oral health in the management of sialorrhea. Twenty children diagnosed with cerebral palsy were randomly assigned to 2 groups. The treatment group received botulinum toxin type A injections, whereas the control received normal saline in the same locations. The authors evaluated subjective drooling scales, salivary flow rate, and oral health (salivary compositions and cariogenic bacterial counts). A significant decrease was found in salivary flow rate at the 1- and 3-month follow-up in the botulinum toxin—treated group. The authors suggest that current protocol can effectively manage sialorrhea while maintaining oral health.Keywords
This publication has 26 references indexed in Scilit:
- Treatment of sialorrhea in children with Cerebral Palsy: A double-blind placebo controlled trialClinical Neurology and Neurosurgery, 2009
- Successful Treatment of Drooling in Children with Neurological Disorders with Botulinum Toxin A or BNeuropediatrics, 2008
- Salivary mutans streptococci counts as indicators in caries risk assessment in 6–7-year-old Chinese childrenJournal of Dentistry, 2007
- Parotid and submandibular botulinum toxin A injections for sialorrhoea in children with cerebral palsyDevelopmental Medicine and Child Neurology, 2006
- Is injection of botulinum toxin type A effective in the treatment of drooling in children with cerebral palsy?Archives of Disease in Childhood, 2006
- Botulinum toxin treatment of sialorrhea: comparing different therapeutic preparationsEuropean Journal of Neurology, 2006
- Social interaction and self-esteem of children with cerebral palsy after treatment for severe droolingEuropean Journal of Pediatrics, 2005
- Effect of Botulinum Toxin in the Treatment of Drooling: A Controlled Clinical TrialPEDIATRICS, 2004
- Prevalence of drooling in children with cerebral palsy attending special schoolsDevelopmental Medicine and Child Neurology, 2003
- The Effect of Submandibular Duct Rerouting in the Treatment of Sialorrhea in ChildrenOtolaryngology -- Head and Neck Surgery, 1981