The protective role of antibody responses duringMycobacterium tuberculosisinfection
- 6 May 2009
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical and Experimental Immunology
- Vol. 157 (2), 235-243
- https://doi.org/10.1111/j.1365-2249.2009.03967.x
Abstract
Summary: Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is one of the most important infectious diseases globally. Immune effector mechanisms that lead to protection or development of clinical disease are not fully known. It is generally accepted that cell-mediated immunity (CMI) plays a pivotal role in controlling Mtb infection, whereas antibody responses are believed to have no protective role. This generalization is based mainly on early classical experiments that lacked standard protocols, and the T helper type 1 (Th1)/Th2 paradigm. According to the Th1/Th2 paradigm Th1 cells protect the host from intracellular pathogens, whereas Th2 cells protect form extracellular pathogens. During the last two decades, the Th1/Th2 paradigm has dominated not only our understanding of immunity to infectious pathogens but also our approach to vaccine design. However, the last few years have seen major discrepancies in this model. Convincing evidence for the protective role of antibodies against several intracellular pathogens has been established. Studies of B cell-deficient mice, severe combined immunodeficiency (SCID) mice, passive immunization using monoclonal (mAb) and polyclonal antibodies and immune responses against specific mycobacterial antigens in experimental animals reveal that, in addition to a significant immunomodulatory effect on CMI, antibodies play an essential protective role against mycobacterial infections. In this review, our current understanding of the essential role of antibodies during Mtb infections, limitations of the Th1/Th2 model and the unfolding interdependence and mutual regulatory relationships between the humoral and CMI will be presented and discussed.Keywords
This publication has 51 references indexed in Scilit:
- Induction of a protective response with an IgA monoclonal antibody against Mycobacterium tuberculosis 16kDa protein in a model of progressive pulmonary infectionInternational Journal of Medical Microbiology, 2009
- Immune Responses and Protective Efficacy of the Gene Vaccine Expressing Ag85B and ESAT6 Fusion Protein fromMycobacterium tuberculosisDNA and Cell Biology, 2008
- Mucosal immunization with recombinant heparin-binding haemagglutinin adhesin suppresses extrapulmonary dissemination of Mycobacterium bovis bacillus Calmette-Guérin (BCG) in infected miceVaccine, 2008
- Current Status of Vaccines for SchistosomiasisClinical Microbiology Reviews, 2008
- TH1 cells control themselves by producing interleukin-10Nature Reviews Immunology, 2007
- TH-17 cells in the circle of immunity and autoimmunityNature Immunology, 2007
- DNA Vaccine UsingMycobacterium bovisAg85B Antigen Induces Partial Protection against Experimental Infection in BALB/c MiceClinical and Vaccine Immunology, 2006
- Enhancement of Innate and Cell-Mediated Immunity by Antimycobacterial AntibodiesInfection and Immunity, 2005
- Lipoarabinomannan‐Reactive Human Secretory Immunoglobulin A Responses Induced by Mucosal Bacille Calmette‐Guérin VaccinationThe Journal of Infectious Diseases, 2003
- TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional PropertiesAnnual Review of Immunology, 1989