Antenatal determinants of neonatal immune responses to allergens
- 1 January 2002
- journal article
- research article
- Published by Wiley in Clinical and Experimental Allergy
- Vol. 32 (1), 43-50
- https://doi.org/10.1046/j.0022-0477.2001.01267.x
Abstract
Background The environmental factors responsible for recent increases in the prevalence of asthma and atopic disease have been assumed to act after birth. Their possible effects on fetal immune development in utero have not been investigated systematically, although sensitization to allergens may occur before birth. Objective This prospective study determined whether the risk factors for asthma and atopic disease, namely family history of atopic disease, maternal smoking, birth order, or maternal dietary intake of antioxidant vitamins, exert antenatal effects on the fetal immune system that may predispose to childhood atopy. Methods The T helper (Th) cell proliferative responses of cord blood mononuclear cells (CBMC) from a sample of 223 neonates, representative of children born to a cohort of 2000 pregnant women, were measured and related to family, maternal and environmental factors associated with the pregnancy. Results The magnitude of CBMC‐proliferative responses to allergens increased significantly in association with a family history of atopic disease or maternal smoking, and decreased significantly with increasing birth order and high maternal dietary intake of vitamin E. The epidemiological association between birth order and atopy may therefore be a consequence of antenatal influences rather than of protective effects of childhood infections. The association between maternal intake of vitamin E and CBMC responsiveness suggests that diet during pregnancy may influence the fetal immune system in such a way as to modulate the risk of childhood atopy. Conclusion These results provide a new insight into the aetiology of atopic disease by demonstrating that the maternal environmental risk factors for atopy, diet, birth order and smoking, influence the development of the fetal immune system. This raises the prospect of preventative public health interventions during pregnancy.Keywords
This publication has 38 references indexed in Scilit:
- Dietary vitamin E, IgE concentrations, and atopyThe Lancet, 2000
- Antioxidant intake and adult-onset wheeze: a case–control studyEuropean Respiratory Journal, 1999
- Decidual and Placental Histologic Findings in Patients Experiencing Spontaneous Abortions in Relation to Pregnancy OrderAmerican Journal of Reproductive Immunology, 1997
- Prenatal allergen contact with milk proteinsClinical and Experimental Allergy, 1997
- Fetal peripheral blood mononuclear cell proliferative responses to mitogenic and allergenic stimuli during gestationPediatric Allergy and Immunology, 1996
- Cord Blood Mononuclear Cell Responsiveness to Beta-Lactoglobulin: T-Cell Activity in ‘Atopy-Prone’ and ‘Non-Atopy-Prone’ NewbornsInternational Archives of Allergy and Immunology, 1994
- Aeroallergen Sensitization Can Occur during Fetal LifeInternational Archives of Allergy and Immunology, 1993
- Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic AsthmaNew England Journal of Medicine, 1992
- TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional PropertiesAnnual Review of Immunology, 1989
- Th1 And Th2 Cells: Different Patterns Of Lymphokine Secretion Lead To Different Functional PropertiesAnnual Review of Immunology, 1989