Refractory Nephrotic Syndrome in Lupus Nephritis: Favorable Response to Indomethacin Therapy
- 1 February 1993
- journal article
- research article
- Published by SAGE Publications in Lupus
- Vol. 2 (1), 9-14
- https://doi.org/10.1177/096120339300200103
Abstract
The effects of indomethacin on urinary protein excretion, levels of serum albumin and renal function were studied prospectively in six patients with systemic lupus erythematosus (SLE) and refractory nephrotic syndrome due to lupus nephritis. Two had membranoproliferative glomerulonephritis, two had diffuse proliferative glomerulonephritis, and one each had mesangioproliferative and membranous glomerulonephritis. All experienced a considerable reduction in urinary protein excretion and an increase in serum albumin. Indomethacin was discontinued in two patients because of side effects, and proteinuria recurred to pretreatment levels. The decrease of proteinuria continued during long-term treatment in three patients. Indomethacin did not cause a permanent decline in renal function. Our results suggest that therapy with indomethacin may be beneficial for the treatment of refractory nephrotic syndrome in selected SLE patients. However, because of potential side effects the administration of indomethacin should be monitored closely.This publication has 25 references indexed in Scilit:
- Antiproteinuric effect of captopril in a patient with lupus nephritis and intractable nephrotic syndrome.Annals Of The Rheumatic Diseases, 1990
- Proteinuria and Progression in Human Glomerular DiseasesAmerican Journal of Nephrology, 1990
- Improvement of Histological and Immunological Change in Steroid and Immunosuppressive Drug-Resistant Lupus nephritis by High-Dose Intravenous Gamma GlobulinNephron, 1989
- Indomethacin reduces proteinuria in passive Heymann nephritis in ratsKidney International, 1987
- Therapy of Lupus NephritisThe New England Journal of Medicine, 1986
- Treatment of Severe Nephrotic Syndrome With Meclofenamate: An Uncontrolled Pilot StudyMayo Clinic Proceedings, 1985
- Antiproteinuric Effect of Naproxen and IndomethacinAmerican Journal of Nephrology, 1985
- Effect of indomethacin on glomerular permeability in the nephrotic syndromeKidney International, 1979
- Aspirin-Induced Depression of Renal FunctionThe New England Journal of Medicine, 1977
- The Effect of Indomethacin on Proteinuria and Kidney Function in the Nephrotic SyndromeActa Medica Scandinavica, 1976