Left ventricular dyssynchrony assessed by two three-dimensional imaging modalities: phase analysis of gated myocardial perfusion SPECT and tri-plane tissue Doppler imaging
Open Access
- 12 September 2007
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Nuclear Medicine and Molecular Imaging
- Vol. 35 (1), 166-173
- https://doi.org/10.1007/s00259-007-0539-6
Abstract
To compare left ventricular (LV) dyssynchrony assessment by phase analysis from gated myocardial perfusion SPECT (GMPS) with LV dyssynchrony assessment by tri-plane tissue Doppler imaging (TDI). Baseline LV dyssynchrony assessed with standard deviation (SD) of time-to-peak systolic velocity of 12 LV segments (Ts-SD) with TDI has proven to be a powerful predictor of response to CRT. Information on LV dyssynchrony can also be provided by GMPS with phase analysis of regional LV maximal count changes throughout the cardiac cycle. Forty heart failure patients, referred for evaluation of potential eligibility for CRT, underwent both 3D echocardiography, with tri-plane TDI, and resting GMPS. From tri-plane TDI, Ts-SD was used as a validated parameter of LV dyssynchrony and compared with different indices (histogram bandwidth, phase SD, histogram skewness and kurtosis) derived from phase analysis of GMPS. Histogram bandwidth and phase SD showed good correlation with Ts-SD (r=0.77 and r=0.74, p<0.0001, respectively). Patients with substantial LV dyssynchrony assessed with tri-plane TDI (Ts-SD ≥33 ms) had also significantly higher values of histogram bandwidth and phase SD. The results of this study support the use of phase analysis by GMPS to evaluate LV dyssynchrony. Histogram bandwidth and phase SD showed the best correlation with Ts-SD assessed with tri-plane TDI and appeared the most optimal variables for assessment of LV dyssynchrony with GMPS.Keywords
This publication has 17 references indexed in Scilit:
- Phase Analysis of Gated Myocardial Perfusion Single-Photon Emission Computed Tomography Compared With Tissue Doppler Imaging for the Assessment of Left Ventricular DyssynchronyJournal of the American College of Cardiology, 2007
- Scar burden by myocardial perfusion imaging predicts echocardiographic response to cardiac resynchronization therapy in ischemic cardiomyopathyAmerican Heart Journal, 2007
- Impact of viability and scar tissue on response to cardiac resynchronization therapy in ischaemic heart failure patientsEuropean Heart Journal, 2006
- Onset of left ventricular mechanical contraction as determined by phase analysis of ECG-gated myocardial perfusion SPECT imaging: Development of a diagnostic tool for assessment of cardiac mechanical dyssynchronyJournal of Nuclear Cardiology, 2005
- A novel tool to assess systolic asynchrony and identify responders of cardiac resynchronization therapy by tissue synchronization imagingJournal of the American College of Cardiology, 2005
- Left ventricular dyssynchrony predicts response and prognosis after cardiac resynchronization therapyJournal of the American College of Cardiology, 2004
- Usefulness of the peak velocity difference by tissue Doppler imaging technique as an effective predictor of response to cardiac resynchronization therapyThe American Journal of Cardiology, 2004
- Interventricular and intraventricular dyssynchrony in idiopathic dilated cardiomyopathyJournal of the American College of Cardiology, 2002
- Cardiac Resynchronization in Chronic Heart FailureNew England Journal of Medicine, 2002
- Predicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with 201Tl and 99mTc-sestamibi.Circulation, 1994