Quality Assessment of Ginseng by 1H NMR Metabolite Fingerprinting and Profiling Analysis
- 5 August 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 57 (16), 7513-7522
- https://doi.org/10.1021/jf901675y
Abstract
Metabolite profiling and fingerprint analysis by 1H NMR spectroscopy were used to identify potential biomarkers capable of distinguishing different ginseng species, varieties, and commercial products with the aim of establishing quality control code protocol based on biochemical phenotype. Principal component (PC) analyses of 1H NMR spectra reliably discriminated between the various ginseng samples, demonstrating the potential utility of metabolomics in the natural health products industry. Four Asian ginseng varieties separated along the PC1 and PC2 axes, and four different Korean ginseng products were divided into two groups by PC1. A strong separation was also revealed between Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius). Glutamine, arginine, sucrose, malate, and myo-inositol were the major metabolites in ginseng samples tested in this study. Combined metabolite fingerprinting and profiling suggested that several compounds including glucose, fumarate, and various amino acids could serve as biomarkers for quality assurance in ginseng.This publication has 30 references indexed in Scilit:
- Botanical characteristics, pharmacological effects and medicinal components of KoreanPanax ginsengC A MeyerActa Pharmacologica Sinica, 2008
- Advances of high-resolution NMR techniques in the structural and metabolic analysis of plant biochemistryPhytochemistry, 2007
- Recent methodology in the phytochemical analysis of ginsengPhytochemical Analysis, 2007
- Effects of Growth Conditions and Processing onRehmannia glutinosausing Fingerprint StrategyPlanta Medica, 2006
- Glucose tetrasaccharide as a biomarker for monitoring the therapeutic response to enzyme replacement therapy for Pompe diseaseMolecular Genetics and Metabolism, 2005
- Classification of Ilex Species Based on Metabolomic Fingerprinting Using Nuclear Magnetic Resonance and Multivariate Data AnalysisJournal of Agricultural and Food Chemistry, 2005
- Metabolomic analysis of Strychnos nux-vomica, Strychnos icaja and Strychnos ignatii extracts by 1H nuclear magnetic resonance spectrometry and multivariate analysis techniquesPhytochemistry, 2004
- Metabolomic Differentiation of Cannabis sativa Cultivars Using 1H NMR Spectroscopy and Principal Component AnalysisJournal of Natural Products, 2004
- GABA in plants: just a metabolite?Trends in Plant Science, 2004
- Factors affecting the robustness of metabolite fingerprinting using 1H NMR spectraPhytochemistry, 2003