Replacement of Hepatitis C Virus Genotype 1b by Genotype 2 Over a 10-year Period in Venezuela
- 1 May 2007
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Clinical Gastroenterology
- Vol. 41 (5), 518-520
- https://doi.org/10.1097/01.mcg.0000248010.55149.ce
Abstract
Background Changes in hepatitis C virus (HCV) genotype distribution with time have been reported in several countries. Goals To explore eventual changes in HCV genotype distribution in Venezuela over a 10 years period. Study HCV genotype was determined by direct sequencing of the 5′ noncoding region, in 236 isolates circulating in patients treated during years 2005 to 2006. Genotype distribution was compared with the one observed in 43 patients followed during years 1994 to 1996. Results The prevalence HCV genotype 1 and 2 was 70% and 26%, respectively, in patients followed during years 1994 to 1996. The frequency of genotype 2 was significantly increased to 41% (P=0.04) in patients treated during years 2005 to 2006. A significant reduction in HCV genotype 1b prevalence (48% to 27%, P=0.01) was also observed after this 10 years period, whereas the prevalence of HCV genotype 1a did not change over time (22% vs. 27%, NS). Transfusion was more significantly associated with infection with HCV genotype 1b than with other genotypes (52% vs. 20%, P=0.002). Conclusions HCV subtype 1b seems to have been displaced by HCV genotype 2 in a relatively short period, without increase in the frequency of genotype 3. The low frequency of HCV genotype 3 in Venezuela might be due to the fact that intravenous drug use in Venezuela is less common than in other countries. The implementation of anti-HCV testing in blood banks since 1994 in Venezuela, might have contributed to the reduction in the frequency HCV genotype 1b infection.Keywords
This publication has 18 references indexed in Scilit:
- Exponential Spread of Hepatitis C Virus Genotype 4a in EgyptJournal of Molecular Evolution, 2004
- Epidemiology of viruses causing chronic hepatitis among populations from the Amazon Basin and related ecosystemsCadernos de Saude Publica, 2003
- 2000 Fleming Lecture. The origin and evolution of hepatitis viruses in humansJournal of General Virology, 2001
- Epidemiology of Hepatitis C: Geographic Differences and Temporal TrendsSeminars in Liver Disease, 2000
- HCV: epidemiology, modes of transmission and prevention of spreadBest Practice & Research Clinical Gastroenterology, 2000
- Clinical Significance of Hepatitis C Virus GenotypesClinical Microbiology Reviews, 2000
- Molecular Epidemiology of Hepatitis C Infection in U.S. Veteran Liver Transplant Recipients: Evidence for Decreasing Relative Prevalence of Genotype 1BThe American Journal of Gastroenterology, 1999
- The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994The New England Journal of Medicine, 1999
- Global surveillance and control of hepatitis CJournal of Viral Hepatitis, 1999
- Prevalence of antibodies to hepatitis A, C, and E viruses in different ethnic groups in French GuianaJournal of Medical Virology, 1997