Interactions Between Electrical Activity and Cortical Microcirculation Revealed by Imaging Spectroscopy: Implications for Functional Brain Mapping
- 26 April 1996
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 272 (5261), 551-554
- https://doi.org/10.1126/science.272.5261.551
Abstract
Modern neuroimaging techniques use signals originating from microcirculation to map brain function. In this study, activity-dependent changes in oxyhemoglobin, deoxyhemoglobin, and light scattering were characterized by an imaging spectroscopy approach that offers high spatial, temporal, and spectral resolution. Sensory stimulation of cortical columns initiates tissue hypoxia and vascular responses that occur within the first 3 seconds and are highly localized to individual cortical columns. However, the later phase of the vascular response is less localized, spreading over distances of 3 to 5 millimeters.Keywords
This publication has 38 references indexed in Scilit:
- Development of identical orientation maps for two eyes without common visual experienceNature, 1996
- Detection of brain activation using oxygenation sensitive functional spectroscopyMagnetic Resonance in Medicine, 1994
- Functional Mapping of the Human Visual Cortex by Magnetic Resonance ImagingScience, 1991
- Iso-orientation domains in cat visual cortex are arranged in pinwheel-like patternsNature, 1991
- Functional architecture of cortex revealed by optical imaging of intrinsic signalsNature, 1986
- Optical recording of action potentials from vertebrate nerve terminals using potentiometric probes provides evidence for sodium and calcium componentsNature, 1983
- Regional cerebral blood flow of the main visual pathways during photic stimulation of the retina in intact and split-brain monkeysExperimental Neurology, 1974
- Light Scattering and Birefringence Changes during Nerve ActivityNature, 1968
- Intracellular Oxidation-Reduction States in VivoScience, 1962
- Intracellular Oxidation-Reduction States in VivoScience, 1962