Efficient Method for Synthesis of Angucyclinone Antibiotics via Gold-Catalyzed Intramolecular [4 + 2] Benzannulation: Enantioselective Total Synthesis of (+)-Ochromycinone and (+)-Rubiginone B2
- 27 September 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 70 (22), 8977-8981
- https://doi.org/10.1021/jo051444m
Abstract
[reaction: see text] An efficient synthetic approach to angucyclinone antibiotics, (+)-ochromycinone and (+)-rubiginone B(2), is reported. The key step involves the facile formation of 2,3-dihydrophenantren-4(1H)-one skeleton, an important framework of angucyclinone natural products, by using gold-catalyzed intramolecular [4 + 2] benzannulation reaction.Keywords
This publication has 11 references indexed in Scilit:
- AuBr3- and Cu(OTf)2-Catalyzed Intramolecular [4 + 2] Cycloaddition of Tethered Alkynyl and Alkenyl Enynones and Enynals: A New Synthetic Method for Functionalized Polycyclic HydrocarbonsThe Journal of Organic Chemistry, 2005
- Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of furanyl (γ)- and pyranyl (δ)-lactolsOrganic & Biomolecular Chemistry, 2004
- Noncovalent π⋅⋅⋅π‐Stacked Exo‐Functional Nanotubes: Subtle Control of Resorcinarene Self‐AssemblyAngewandte Chemie-International Edition, 2004
- Lewis Acid-Catalyzed Benzannulation via Unprecedented [4+2] Cycloaddition of o-Alkynyl(oxo)benzenes and Enynals with AlkynesJournal of the American Chemical Society, 2003
- Pd/P(t-Bu)3: A Mild and General Catalyst for Stille Reactions of Aryl Chlorides and Aryl BromidesJournal of the American Chemical Society, 2002
- YM-181741, a Novel Benz[a]anthraquinone Antibiotic with Anti-Helicobacter pylori Activity from Streptomyces sp.The Journal of Antibiotics, 2002
- Potentiation of vincristine cytotoxicity by rubiginone B1 and piperafizine A in human moser and K562 cells-Mode of action.The Journal of Antibiotics, 1992
- Biosynthesis of vineomycins A1 and B2.The Journal of Antibiotics, 1982
- Regiospecific synthesis of bromojuglone derivativesTetrahedron Letters, 1980
- The structure of aquayamycinTetrahedron, 1970