Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting - a review
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- 18 February 2007
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 59 (2), 209-223
- https://doi.org/10.1211/jpp.59.2.0008
Abstract
Terahertz pulsed spectroscopy (TPS) and terahertz pulsed imaging (TPI) are two novel techniques for the physical characterization of pharmaceutical drug materials and final solid dosage forms, utilizing spectral information in the far infrared region of the electromagnetic spectrum. This review focuses on the development and performance of pharmaceutical applications of terahertz technology compared with other tools for physical characterization. TPS can be used to characterize crystalline properties of drugs and excipients. Different polymorphic forms of a drug can be readily distinguished and quantified. Recent developments towards a better understanding of the fundamental theory behind spectroscopy in the far infrared have been discussed. Applications for TPI include the measurement of coating thickness and uniformity in coated pharmaceutical tablets, structural imaging and 3D chemical imaging of solid dosage forms.Keywords
This publication has 70 references indexed in Scilit:
- Solid-State Modeling of the Terahertz Spectrum of the High Explosive HMXThe Journal of Physical Chemistry A, 2006
- Cultivating crystal formsChemical Communications, 2005
- Imaging with THz quantum cascade lasers using a Schottky diode mixerOptics Express, 2005
- 2.9 THz quantum cascade lasers operating up to 70K in continuous waveApplied Physics Letters, 2004
- Terahertz SpectroscopyThe Journal of Physical Chemistry B, 2002
- Characterization of the solid-state: spectroscopic techniquesAdvanced Drug Delivery Reviews, 2001
- Sulfathiazole polymorphism studied by magic-angle spinning NMRJournal of Pharmaceutical Sciences, 1999
- Quantitation of cefepime · 2HCl dihydrate in cefepime · 2HCl monohydrate by diffuse reflectance IR and powder X-ray diffraction techniquesJournal of Pharmaceutical and Biomedical Analysis, 1996
- Solid-State Nuclear Magnetic Resonance Spectroscopy: Theory and Pharmaceutical ApplicationsPharmaceutical Research, 1993
- Picosecond optoelectronic switching and gating in siliconApplied Physics Letters, 1975