Circular RNA – New member of noncoding RNA with novel functions
Top Cited Papers
- 9 May 2017
- journal article
- review article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 242 (11), 1136-1141
- https://doi.org/10.1177/1535370217708978
Abstract
The accumulating evidence indicate that circular RNA (circRNA) is a novel class of noncoding RNA with diverse molecular functions. Our review summarizes the current hypotheses for the models of circRNA biosynthesis including the direct interaction between upstream and downstream introns and lariat-driven circularization. In addition, molecular functions such as a decoy of microRNA (miRNA) termed miRNA sponge, transcriptional regulator, and protein-like modulator are also discussed. Finally, we reviewed the potential roles of circRNAs in neural system, cardiovascular system as well as cancers. These should provide insightful information for studying the regulation and functions of circRNA in other model of human diseases.Keywords
Funding Information
- Ministry of Science and Technology, Taiwan (MOST 104-2320-B-006-036-MY3)
- National Health Research Institutes (NHRI-EX102- 10244BI)
This publication has 42 references indexed in Scilit:
- Rbm20 regulates titin alternative splicing as a splicing repressorNucleic Acids Research, 2013
- Circular RNAs are abundant, conserved, and associated with ALU repeatsRNA, 2012
- RBM20, a gene for hereditary cardiomyopathy, regulates titin splicingNature Medicine, 2012
- Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell TypesPLOS ONE, 2012
- Long Noncoding RNA as Modular Scaffold of Histone Modification ComplexesScience, 2010
- Dendritic mRNA: transport, translation and functionNature Reviews Neuroscience, 2007
- Circular transcripts of the testis-determining gene Sry in adult mouse testisCell, 1993
- Scrambled exonsCell, 1991
- A pathway of cytochrome b mRNA processing in yeast mitochondria: Specific splicing steps and an intron-derived circular RNACell, 1980
- Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cellsNature, 1979