Genotoxic hazard of radiopharmaceuticals in humans: chemical and radiation aspects coupled to microdosing
- 25 April 2007
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Clinical Pharmacology
- Vol. 63 (7), 641-645
- https://doi.org/10.1007/s00228-007-0304-6
Abstract
To obtain the pharmacokinetic properties of drug candidates at an early stage of the development process, a microdosing (phase 0) concept to radiolabel drug candidates and administer them at subtoxic mass to a few volunteers has been suggested. Radiopharmaceuticals are special in the sense that the chemical carrier might be genotoxic, whereas it is well established that ionizing radiation coupled to the molecule is genotoxic, and that the mechanism that causes cancer is similar to certain genotoxic chemicals.This publication has 12 references indexed in Scilit:
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