Motor-Cortical Interaction in Gilles de la Tourette Syndrome
Open Access
- 4 January 2012
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 7 (1), e27850
- https://doi.org/10.1371/journal.pone.0027850
Abstract
In Gilles de la Tourette syndrome (GTS) increased activation of the primary motor cortex (M1) before and during movement execution followed by increased inhibition after movement termination was reported. The present study aimed at investigating, whether this activation pattern is due to altered functional interaction between motor cortical areas. 10 GTS-patients and 10 control subjects performed a self-paced finger movement task while neuromagnetic brain activity was recorded using Magnetoencephalography (MEG). Cerebro-cerebral coherence as a measure of functional interaction was calculated. During movement preparation and execution coherence between contralateral M1 and supplementary motor area (SMA) was significantly increased at beta-frequency in GTS-patients. After movement termination no significant differences between groups were evident. The present data suggest that increased M1 activation in GTS-patients might be due to increased functional interaction between SMA and M1 most likely reflecting a pathophysiological marker of GTS. The data extend previous findings of motor-cortical alterations in GTS by showing that local activation changes are associated with alterations of functional networks between premotor and primary motor areas. Interestingly enough, alterations were evident during preparation and execution of voluntary movements, which implies a general theme of increased motor-cortical interaction in GTS.This publication has 58 references indexed in Scilit:
- Is it a tic?—Twenty seconds to make a diagnosisMovement Disorders, 2010
- Brain Areas Coactivating with Motor Cortex During Chronic Motor Tics and Intentional MovementsBiological Psychiatry, 2008
- Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI studyBrain, 2006
- Neurobiology of basal ganglia and Tourette syndrome: basal ganglia circuits and thalamocortical outputs.2006
- Motor inhibition in patients with Gilles de la Tourette syndrome: functional activation patterns as revealed by EEG coherenceBrain, 2004
- Premonitory sensory phenomenon in Tourette's syndromeMovement Disorders, 2003
- Basal ganglia dysfunction in Tourette’s syndrome: a new hypothesisPediatric Neurology, 2001
- Tourette's SyndromeNeuron, 2000
- A Functional Neuroanatomy of Tics in Tourette SyndromeArchives of General Psychiatry, 2000
- Decreased motor inhibition in Tourette's disorder: evidence from transcranial magnetic stimulationAmerican Journal of Psychiatry, 1997