Particulate matter and the airway epithelium: the special case of the underground?
Open Access
- 25 September 2019
- journal article
- review article
- Published by European Respiratory Society (ERS) in European Respiratory Review
- Vol. 28 (153), 190066
- https://doi.org/10.1183/16000617.0066-2019
Abstract
Airborne particulate matter (PM) is a leading driver of premature mortality and cardiopulmonary morbidity, associated with exacerbations of asthma and chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and lung cancer. The airway epithelium, as the principal site of PM deposition, is critical to the effects of, and initial response to, PM. A key mechanism by which PM exerts its effects is the generation of reactive oxygen species (ROS), inducing antioxidant and inflammatory responses in exposed epithelial cells. However, much of what is known about the effects of PM is based on research using particulates from urban air. PM from underground railways is compositionally highly distinct from urban PM, being rich in metals associated with wheel, rail and brake wear and electrical arcing and component wear, which endows underground PM with potent ROS-generating capacity. In addition, underground PM appears to be more inflammogenic than urban PM in epithelial cells, but there is a lack of research into effects on exposed individuals, especially those with underlying health conditions. This review summarises current knowledge about the effects of PM on the airway epithelium, how the effects of underground PM may be different to urban PM and the potential health consequences and mitigation strategies for commuters and workers in underground railways.Keywords
This publication has 110 references indexed in Scilit:
- Physicochemical Characterization of Airborne Particulate Matter at a Mainline Underground Railway StationEnvironmental Science & Technology, 2013
- Respiratory Health Effects of Airborne Particulate Matter: The Role of Particle Size, Composition, and Oxidative Potential—The RAPTES ProjectEnvironmental Health Perspectives, 2012
- Reducing Personal Exposure to Particulate Air Pollution Improves Cardiovascular Health in Patients with Coronary Heart DiseaseEnvironmental Health Perspectives, 2012
- ER stress activates the NLRP3 inflammasome via an UPR-independent pathwayCell Death & Disease, 2012
- In vitro toxicity of particulate matter (PM) collected at different sites in the Netherlands is associated with PM composition, size fraction and oxidative potential - the RAPTES projectParticle and Fibre Toxicology, 2011
- Ambient particulate matter affects occludin distribution and increases alveolar transepithelial electrical conductanceRespirology, 2010
- Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissuesAmerican Journal of Physiology-Cell Physiology, 2010
- Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matterJournal of Leukocyte Biology, 2009
- Beneficial cardiovascular effects of reducing exposure to particulate air pollution with a simple facemaskParticle and Fibre Toxicology, 2009
- The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticlesFree Radical Biology & Medicine, 2008