Skeletal muscle fibre diversity and the underlying mechanisms
- 1 July 2010
- journal article
- review article
- Published by Wiley in Acta Physiologica
- Vol. 199 (4), 465-476
- https://doi.org/10.1111/j.1748-1716.2010.02118.x
Abstract
The review first briefly summarizes how myosin isoforms have been identified as the major determinant of the functional variability among skeletal muscle fibres. The latter feature is a major characteristic of muscle fibres and a major basis of skeletal muscle heterogeneity and plasticity in vivo. Then, evidence is reported, which indicates that the properties of muscle fibres can vary with no change in the myosin isoform they express. Moreover, the physiological and pathological conditions (ageing, disuse, exercise training, muscular dystrophy) in which such myosin isoform independent change in functional properties occurs and the possible underlying mechanisms are considered. Finally, the known molecular bases of the functional differences among slow and fast isoforms are briefly dealt with.Keywords
This publication has 96 references indexed in Scilit:
- Improvements in whole muscle and myocellular function are limited with high-intensity resistance training in octogenarian womenJournal of Applied Physiology, 2009
- Single muscle fiber adaptations to resistance training in old (>80 yr) men: evidence for limited skeletal muscle plasticityAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008
- Structural and functional alterations of muscle fibres in the novel mouse model of facioscapulohumeral muscular dystrophyThe Journal of Physiology, 2007
- The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in ratsAmerican Journal of Physiology-Cell Physiology, 2007
- Effects of hindlimb unweighting and aging on rat semimembranosus muscle and myosinJournal of Applied Physiology, 2006
- Differing ADP Release Rates from Myosin Heavy Chain Isoforms Define the Shortening Velocity of Skeletal Muscle FibersJournal of Biological Chemistry, 2001
- Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity 1 1Edited by J. KarnJournal of Molecular Biology, 1999
- Three myosin heavy chain isoforms in type 2 skeletal muscle fibresJournal of Muscle Research and Cell Motility, 1989
- Three fast myosin heavy chains in adult rat skeletal muscleFEBS Letters, 1988
- Comparison of the myosin and actomyosin ATPase mechanisms of the four types of vertebrate musclesJournal of Molecular Biology, 1980