V. Stress and irritable bowel syndrome
Top Cited Papers
- 1 April 2001
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Gastrointestinal and Liver Physiology
- Vol. 280 (4), G519-G524
- https://doi.org/10.1152/ajpgi.2001.280.4.g519
Abstract
Different types of stress play important roles in the onset and modulation of irritable bowel syndrome (IBS) symptoms. The physiological effects of psychological and physical stressors on gut function and brain-gut interactions are mediated by outputs of the emotional motor system in terms of autonomic, neuroendocrine, attentional, and pain modulatory responses. IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility and secretion and in alterations in the perception of visceral events. Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome.Keywords
This publication has 32 references indexed in Scilit:
- A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal developmentGastroenterology, 2000
- Gender differences in regional brain response to visceral pressure in IBS patientsEuropean journal of pain, 2000
- Stress Hormones, Th1/Th2 patterns, Pro/Anti-inflammatory Cytokines and Susceptibility to DiseaseTrends in Endocrinology & Metabolism, 1999
- Laser Doppler measurement of rectal mucosal blood flowGut, 1999
- Stress and Visceral PerceptionCanadian Journal of Gastroenterology, 1999
- Effect of ondansetron, a 5-HT3 receptor antagonist, on the dynamic association between bulimic behaviors and pain thresholdsPain, 1998
- Subgenual prefrontal cortex abnormalities in mood disordersNature, 1997
- Predominant symptoms in irritable bowel syndrome correlate with specific autonomic nervous system abnormalitiesGastroenterology, 1994
- Assessment of central noradrenergic functioning in irritable bowel syndrome using a neuroendocrine challenge testJournal of Psychosomatic Research, 1990
- Levels of Anxiety in Colonic DisordersNew England Journal of Medicine, 1973