Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia
Open Access
- 17 April 2014
- journal article
- Published by American Society of Hematology in Blood
- Vol. 123 (16), 2518-2529
- https://doi.org/10.1182/blood-2013-02-486688
Abstract
Key Points Zebrafish flt3 plays an important role in the initiation of definitive hematopoietic stem cells. Expression of human FLT3-ITD activates endogenous flt3 signaling and induces myeloid expansion.Keywords
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