Link between retinopathy and nephropathy caused by complications of diabetes mellitus type 2
- 13 November 2014
- journal article
- Published by Springer Science and Business Media LLC in International Ophthalmology
- Vol. 35 (1), 59-66
- https://doi.org/10.1007/s10792-014-0018-6
Abstract
While the correlation and chronology of appearance of diabetic nephropathy and retinopathy is well known in diabetes mellitus (DM) type 1 patients, in DM type 2 this correlation is less clear. A retrospective study including 917 patients with type 2 diabetes. Diabetic retinopathy (DR) was diagnosed based on fundus photographs taken with a non-mydriatic camera. Diabetic nephropathy (DN) was diagnosed based on urinary albumin concentration in a morning urine sample. Statistical analysis was performed with a seemingly unrelated regression (SUR) model. Our SUR model is statistically significant: the test for “model versus saturated” is 2.20 and its significance level is 0.8205. The model revealed that creatinine and glomerular filtration rate (GFR) have strong influence on albuminuria, while body mass index (BMI) and HbA1c have less significant impact. DR is affected positively by diabetes duration, insulin treatment, glucose levels, and HbA1c, and it is affected negatively by GFR, triglyceride levels, and BMI. The association between DR and DN was statistically significant and had a unidirectional correlation, which can be explained by chronological order; that is, DN precedes DR. The present study indicates that the level of renal impairment is proportional to the level of damage to the eye. Furthermore, such an association has a chronological aspect; the renal injury precedes retinal damage.Keywords
This publication has 26 references indexed in Scilit:
- Standards of Medical Care in Diabetes—2012Diabetes Care, 2011
- Socioeconomic status and race/ethnicity independently predict health decline among older diabeticsBMC Public Health, 2011
- Albuminuria and Diabetic Retinopathy in Type 2 Diabetes Mellitus Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetic Study (SN-DREAMS, report 12)Diabetology & Metabolic Syndrome, 2011
- Disparities in diabetes care: role of the patient's socio-demographic characteristicsBMC Public Health, 2010
- The Economic Burden Of DiabetesHealth Affairs, 2010
- Early Detection of Chronic Kidney Disease: Results of the PolNef StudyAmerican Journal of Nephrology, 2008
- Screening of diabetic retinopathy: Effect of field number and mydriasis on sensitivity and specificity of digital fundus photographyDiabetes & Metabolism, 2008
- The validity of screening based on spot morning urine samples to detect subjects with microalbuminuria in the general populationKidney International, 2005
- Microalbuminuria in non-insulin-dependent (type 2) Nigerian diabetics: relation to glycaemic control, blood pressure and retinopathyHeart, 1992
- An Efficient Method of Estimating Seemingly Unrelated Regressions and Tests for Aggregation BiasJournal of the American Statistical Association, 1962