Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first?
- 1 November 1980
- journal article
- abstracts
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 62 (5), 945-952
- https://doi.org/10.1161/01.cir.62.5.945
Abstract
Both microvascular damage and myocardial cell injury occur after coronary occlusion, but the relationship of these two events is unclear; specifically, it is unknown whether microvascular damage causes myocardial cell injury. Dogs were subjected to coronary occlusion for 20, 40, 60, 90 or 180 minutes, after which subendocardial and subepicardial biopsies were obtained for electron and light microscopy of 1-mu sections. Of 312 biopsies of ischemic myocadium, 181 showed myocardial cell injury with no microvascular damage; 131 showed myocardial cell injury and microvascular damage; but none showed microvascular damage without myocardial cell injury. Although ultrastructural evidence of myocardial cell damage was present in the subendocardium after 20-40 minutes of ischemia, ultrastructural evidence of microvascular damage was not prominent until 60-90 minutes after coronary artery occlusion. Morphologic ultrastructural evidence of microvascular damage lagged behind myocardial cell injury, suggesting that ultrastructural microvascular damage is not a primary cause of ultrastructural myocardial cell injury.Keywords
This publication has 10 references indexed in Scilit:
- The no-reflow phenomenon: Not a time-limiting factor for reperfusion following coronary occlusionThe American Journal of Cardiology, 1980
- Early ischemic ultrastructural and histochemical alterations in the myocardium of the rat following coronary artery occlusionExperimental and Molecular Pathology, 1979
- Effect of hyaluronidase during the early phase of acute myocardial ischemia: An ultrastructural and morphometric analysisThe American Journal of Cardiology, 1977
- The effect of coronary artery reperfusion on the extent of myocardial infarctionAmerican Heart Journal, 1977
- Microcirculatory changes following early reperfusion in experimentel myocardial infarctionVirchows Archiv, 1976
- Acute myocardial infarctionThe Journal of Thoracic and Cardiovascular Surgery, 1975
- Reduced myocardial reflow and increased coronary vascular resistance following prolonged myocardial ischemia in the dog.Circulation Research, 1975
- The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the DogJCI Insight, 1974
- Aorto-coronary bypass for acute coronary occlusionThe Journal of Thoracic and Cardiovascular Surgery, 1972