The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease
- 8 November 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 66 (4), 565-583
- https://doi.org/10.1007/s00018-008-8335-4
Abstract
The sine oculis homeobox (SIX) protein family is a group of evolutionarily conserved transcription factors that are found in diverse organisms that range from flatworms to humans. These factors are expressed within, and play pivotal developmental roles in, cell populations that give rise to the head, retina, ear, nose, brain, kidney, muscle and gonads. Mutations within the fly and mammalian versions of these genes have adverse consequences on the development of these organs/tissues. Several SIX proteins have been shown to directly influence the cell cycle and are present at elevated levels during tumorigenesis and within several cancers. This review aims to highlight aspects of (1) the evolutionary history of the SIX family; (2) the structural differences and similarities amongst the different SIX proteins; (3) the role that these genes play in retinal development; and (4) the influence that these proteins have on cell proliferation and growth.Keywords
This publication has 97 references indexed in Scilit:
- Mechanisms of transcriptional regulation by Rb-E2F segregate by biological pathwayOncogene, 2003
- Tissue-Specific Regulation of Retinal and Pituitary Precursor Cell ProliferationScience, 2002
- Exclusion ofSIX6 hemizygosity in a child with anophthalmia, panhypopituitarism and renal failureAmerican Journal of Medical Genetics, 2001
- Combinatorial Signaling in the Specification of Unique Cell FatesCell, 2000
- Interaction of Xenopus Cdc2·Cyclin A1 with the Origin Recognition ComplexOnline Journal of Public Health Informatics, 2000
- Genomic Cloning, Structure, Expression Pattern, and Chromosomal Location of the HumanSIX3GeneGenomics, 1999
- Identification and expression of six family genes in mouse retinaFEBS Letters, 1996
- p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21Cell, 1994
- The structure and function of the homeodomainBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1989
- Cell degeneration in the developing optic lobes of the sine oculis and small-optic-lobes mutants of Drosophila melanogasterDevelopmental Biology, 1984