ErbB4 (JM-b/CYT-1)-induced expression and phosphorylation of c-Jun is abrogated by human papillomavirus type 16 E5 protein
- 3 July 2006
- journal article
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 26 (1), 42-53
- https://doi.org/10.1038/sj.onc.1209768
Abstract
Human papillomavirus type 16 E5 (HPV-16 E5) is a highly hydrophobic membrane protein with weak-transforming activity, which is associated with ErbB4 receptor in HPV-16-infected cervical lesions. Presently, we investigated the transforming mechanisms of E5 involving ErbB4 signaling. Firstly, we report a role for ErbB4 (JM-b/CYT-1) receptor that activates c-jun gene expression and phosphorylating at Ser63 and Ser73 of the c-Jun protein in ligand-independent and Ras-c-jun NH2-terminal kinase-dependent pathway. Secondly, we show that HPV-16 E5 protein can form a complex with ErbB4 via binding to the extracellular and transmembrane domains of ErbB4 (JM-b/CYT-1). When co-expressing HPV-16 E5 and ErbB4 in cells, E5 can abrogate ErbB4-induced c-Jun protein expression and phosphorylation resulted in increasing cell proliferation compared to ErbB4-expressing cells. The interaction between of HPV-16 E5 and ErbB4 provides more insight into the mechanisms of HPV-16 E5 transformation induction.Keywords
This publication has 61 references indexed in Scilit:
- WW Domain–Containing Proteins, WWOX and YAP, Compete for Interaction with ErbB-4 and Modulate Its Transcriptional FunctionCancer Research, 2005
- Presenilin-dependent γ-Secretase Processing Regulates Multiple ERBB4/HER4 ActivitiesJournal of Biological Chemistry, 2005
- Impaired differentiation and lactational failure ofErbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5Development, 2003
- The biochemical and biological functions of human papillomavirus type 16 E5 proteinArchiv für die gesamte Virusforschung, 2003
- Papillomaviruses and cancer: from basic studies to clinical applicationNature Reviews Cancer, 2002
- Role of ATM in Oxidative Stress-mediated c-Jun Phosphorylation in Response to Ionizing Radiation and CdCl2Published by Elsevier BV ,2001
- The expression of HPV-16 E5 protein in squamous neoplastic changes in the uterine cervixJournal of Biomedical Science, 2001
- A Novel Juxtamembrane Domain Isoform of HER4/ErbB4Journal of Biological Chemistry, 1997
- ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signalingThe EMBO Journal, 1997
- Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5Journal of General Virology, 1977