No requirement of reactive oxygen intermediates in Fas‐mediated apoptosis
- 12 September 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 351 (3), 311-313
- https://doi.org/10.1016/0014-5793(94)00852-3
Abstract
Fas is a cell surface molecule that mediates apoptosis, but the intracellular mechanisms leading to apoptosis are not well understood. It is known that diethylmaleate (DEM)-induced cell death can be blocked by substances with antioxidant activity. Here we have studied whether antioxidants have any effect on Fas-mediated apoptosis and show that they are not able to block Fas-mediated apoptosis. Therefore, it seems that reactive oxygen intermediate (ROI)-dependent and -independent mechanisms which lead to apoptosis do exist. Fas-mediated apoptosis probably proceeds via a ROI-independent pathwayKeywords
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