EFFECT OF ACUTE METABOLIC ACIDOSIS AND ALKALOSIS ON ACETATE AND CITRATE METABOLISM IN THE RAT*
Open Access
- 1 February 1963
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 42 (2), 137-142
- https://doi.org/10.1172/jci104700
Abstract
The mechanism of the altered urinary citrate excretion in acute metabolic alkalosis and in acute metabolic acidosis was studied in rats. Systemic pH in-fluences the renal clearance of plasma citrate-C14. The data are consistent with the mechanism of increased tubular reabsorption of filtered citrate in acidosis and decreased tubular reabsorption of filtered citrate in alkalosis. Data was presented which suggest that there is a continuous synthesis and release of citrate from extra-renal tissues, and that alkali administration does not influence this process. The evidence for a relationship between citrate metabolism by the kidney and citrate excretion in the urine, was summarized.Keywords
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