Expression of Renin-Angiotensin System Components in the Taste Organ of Mice
Open Access
- 19 September 2019
- Vol. 11 (9), 2251
- https://doi.org/10.3390/nu11092251
Abstract
The systemic renin-angiotensin system (RAS) is an important regulator of body fluid and sodium homeostasis. Angiotensin II (AngII) is a key active product of the RAS. We previously revealed that circulating AngII suppresses amiloride-sensitive salt taste responses and enhances the responses to sweet compounds via the AngII type 1 receptor (AT1) expressed in taste cells. However, the molecular mechanisms underlying the modulation of taste function by AngII remain uncharacterized. Here we examined the expression of three RAS components, namely renin, angiotensinogen, and angiotensin-converting enzyme-1 (ACE1), in mouse taste tissues. We found that all three RAS components were present in the taste buds of fungiform and circumvallate papillae and co-expressed with αENaC (epithelial sodium channel α-subunit, a salt taste receptor) or T1R3 (taste receptor type 1 member 3, a sweet taste receptor component). Water-deprived mice exhibited significantly increased levels of renin expression in taste cells (p < 0.05). These results indicate the existence of a local RAS in the taste organ and suggest that taste function may be regulated by both locally-produced and circulating AngII. Such integrated modulation of peripheral taste sensitivity by AngII may play an important role in sodium/calorie homeostasis.Funding Information
- The Ministry of Education, Culture, Sports, Science and Technology of Japan (Grants-in-Aid for Scientific Research 15K11044, 18K19652 and 19H03818 (N.S.), 18077004 and 18109013 (Y.N.))
This publication has 55 references indexed in Scilit:
- Intrarenal angiotensin II and its contribution to the genesis of chronic hypertensionCurrent Opinion in Pharmacology, 2011
- The cells and peripheral representation of sodium taste in miceNature, 2010
- Endocannabinoids selectively enhance sweet tasteProceedings of the National Academy of Sciences of the United States of America, 2009
- Renin‐angiotensin system revisitedJournal of Internal Medicine, 2008
- Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidneyProceedings of the National Academy of Sciences of the United States of America, 2006
- The cells and logic for mammalian sour taste detectionNature, 2006
- Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptorProceedings of the National Academy of Sciences of the United States of America, 2006
- Heat activation of TRPM5 underlies thermal sensitivity of sweet tasteNature, 2005
- Coding of Sweet, Bitter, and Umami Tastes: Different Receptor Cells Sharing Similar Signaling PathwaysCell, 2003
- A transient receptor potential channel expressed in taste receptor cellsNature Neuroscience, 2002