Massive Cortical Reorganization After Sensory Deafferentation in Adult Macaques
- 28 June 1991
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 252 (5014), 1857-1860
- https://doi.org/10.1126/science.1843843
Abstract
After limited sensory deafferentations in adult primates, somatosensory cortical maps reorganize over a distance of 1 to 2 millimeters mediolaterally, that is, in the dimension along which different body parts are represented. This amount of reorganization was considered to be an upper limit imposed by the size of the projection zones of individual thalamocortical axons, which typically also extend a mediolateral distance of 1 to 2 millimeters. However, after extensive long-term deafferentations in adult primates, changes in cortical maps were found to be an order of magnitude greater than those previously described. These results show the need for a reevaluation of both the upper limit of cortical reorganization in adult primates and the mechanisms responsible for it.Keywords
This publication has 21 references indexed in Scilit:
- A Map of Visual Space Induced in Primary Auditory CortexScience, 1990
- Morphology of single intracellularly stained axons terminating in area 3b of macaque monkeysJournal of Comparative Neurology, 1990
- Reorganization of Retinotopic Cortical Maps in Adult Mammals After Lesions of the RetinaScience, 1990
- The Arbors of Axons Terminating in Middle Cortical Layers of Somatosensory Area 3b in Owl MonkeysSomatosensory & Motor Research, 1989
- Static and Dynamic Aspects of Cortical Somatotopy: A Critical EvaluationJournal of Cognitive Neuroscience, 1989
- Consistent Features of the Representation of the Hand in Area 3b of Macaque MonkeysSomatosensory Research, 1987
- Cortical connections of the somatosensory fields of the lateral sulcus of macaques: Evidence for a corticolimbic pathway for touchJournal of Comparative Neurology, 1986
- Reorganization of mammalian somatosensory cortex following peripheral nerve injuryTrends in Neurosciences, 1982
- Representations of the body surface in postcentral parietal cortex of Macaca fascicularisJournal of Comparative Neurology, 1980
- Intracortical connectivity of architectonic fields in the somatic sensory, motor and parietal cortex of monkeysJournal of Comparative Neurology, 1978