In Vitro Activity of the New Fluoroketolide Solithromycin (CEM-101) against a Large Collection of Clinical Neisseria gonorrhoeae Isolates and International Reference Strains, Including Those with High-Level Antimicrobial Resistance: Potential Treatment Option for Gonorrhea?
Open Access
- 1 May 2012
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 56 (5), 2739-2742
- https://doi.org/10.1128/aac.00036-12
Abstract
Gonorrhea may become untreatable, and new treatment options are essential. We investigated the in vitro activity of the first fluoroketolide, solithromycin. Clinical Neisseria gonorrhoeae isolates and reference strains ( n = 246), including the two extensively drug-resistant strains H041 and F89 and additional isolates with clinical cephalosporin resistance and multidrug resistance, were examined. The activity of solithromycin was mainly superior to that of other antimicrobials ( n = 10) currently or previously recommended for gonorrhea treatment. Solithromycin might be an effective treatment option for gonorrhea.Keywords
This publication has 39 references indexed in Scilit:
- High-Level Cefixime- and Ceftriaxone-Resistant Neisseria gonorrhoeae in France: Novel penA Mosaic Allele in a Successful International Clone Causes Treatment FailureAntimicrobial Agents and Chemotherapy, 2012
- Trends in Antimicrobial Resistance in Neisseria gonorrhoeae Isolated in Canada: 2000–2009Sexually Transmitted Diseases, 2011
- Is Neisseria gonorrhoeae Initiating a Future Era of Untreatable Gonorrhea?: Detailed Characterization of the First Strain with High-Level Resistance to CeftriaxoneAntimicrobial Agents and Chemotherapy, 2011
- High-Level Azithromycin Resistance Occurs in Neisseria gonorrhoeae as a Result of a Single Point Mutation in the 23S rRNA GenesAntimicrobial Agents and Chemotherapy, 2010
- CEM-101 Activity against Gram-Positive OrganismsAntimicrobial Agents and Chemotherapy, 2010
- New Mutation in 23S rRNA Gene Associated with High Level of Azithromycin Resistance in Neisseria gonorrhoeaeAntimicrobial Agents and Chemotherapy, 2010
- In Vitro Activity of CEM-101, a New Fluoroketolide Antibiotic, against Chlamydia trachomatis and Chlamydia ( Chlamydophila ) pneumoniaeAntimicrobial Agents and Chemotherapy, 2010
- In Vitro Activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with Defined Macrolide Resistance MechanismsAntimicrobial Agents and Chemotherapy, 2010
- Cellular Accumulation and Pharmacodynamic Evaluation of the Intracellular Activity of CEM-101, a Novel Fluoroketolide, againstStaphylococcus aureus,Listeria monocytogenes, andLegionella pneumophilain Human THP-1 MacrophagesAntimicrobial Agents and Chemotherapy, 2009
- Comparative In Vitro Susceptibilities of Human Mycoplasmas and Ureaplasmas to a New Investigational Ketolide, CEM-101Antimicrobial Agents and Chemotherapy, 2009