Mesenchymal stromal cell ‘licensing’: a multistep process
- 27 May 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Leukemia
- Vol. 25 (9), 1408-1414
- https://doi.org/10.1038/leu.2011.108
Abstract
Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenvironment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects.Keywords
This publication has 100 references indexed in Scilit:
- Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12Molecular Cancer, 2010
- Pro-Inflammatory Cytokines, IFNγ and TNFα, Influence Immune Properties of Human Bone Marrow and Wharton Jelly Mesenchymal Stem Cells DifferentiallyPLOS ONE, 2010
- Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors: Implications on Therapeutic PotentialMediators of Inflammation, 2010
- Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic CancerCancer Research, 2009
- VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinomaBritish Journal of Cancer, 2008
- Cancer-related inflammationNature, 2008
- IFN‐γ activation of mesenchymal stem cells for treatment and prevention of graft versus host diseaseEuropean Journal of Immunology, 2008
- The role of IL-6 in inhibition of lymphocyte apoptosis by mesenchymal stem cellsBiochemical and Biophysical Research Communications, 2007
- Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and WoundsPLoS Biology, 2004
- Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stromaProceedings of the National Academy of Sciences of the United States of America, 2003