The macro-ethics of genomics to health: the Physiome Project
- 1 October 2003
- journal article
- Published by Cellule MathDoc/CEDRAM in Comptes Rendus Biologies
- Vol. 326 (10-11), 1105-1110
- https://doi.org/10.1016/j.crvi.2003.09.006
Abstract
Advances in pharmacology and genomics, and their intervention in human biology are beyond our abilities to understand their consequences. Therapeutic intervention in highly complex, non-linear, adaptive biological systems results in some unforeseen and undesirable consequences. To do the most good with the least harm, the information on biological systems should be gathered into databases, and into comprehensive quantitative models that can help to predict the long-range effects of proposed interventions. This is a societal or professional macro-ethical imperative. The Physiome Project helps to meet this imperative via databasing and creating models and tools for large-scale integration. To cite this article: J.B. Bassingthwaighte, C. R. Biologies 326 (2003). Les avancées en pharmacologie et en génomique ainsi que leur intervention en biologie humaine vont au-delà de notre compréhension de leurs conséquences. L'intervention thérapeutique sur des systèmes biologiques hautement complexes, non linéaires et adaptables, provoque des conséquences imprévisibles et indésirables. De manière à faire le plus de bien possible et le moindre mal, l'information sur les systèmes biologiques doit être regroupée dans des modèles quantitatifs qui prédisent les effets à longue portée des interventions proposées. Ceci est un impératif macro-éthique sociétal ou professionnel, et le projet Physiome fournit un moyen d'y faire face en créant des outils d'intégration à grande échelle. Pour citer cet article : J.B. Bassingthwaighte, C. R. Biologies 326 (2003).Keywords
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