Experimental treatment of chronic Trypanosoma cruzi infection in mice with 2‐n‐propylquinoline

Abstract

It was reported previously that 2‐n‐propylquinoline was active against the epimastigote form of Trypanosoma cruzi. The effects of oral treatments with benznidazole and 2‐n‐propylquinoline were evaluated in Balb/c mice infected with T. cruzi chronically. The reference drug and 2‐n‐propylquinoline were administered 60 days post‐infection for 30 days at 25 mg/mL. At 35 days post‐treatment, the serological tests (ELISA) of the 2‐n‐ propylquinoline‐treated mice were significantly different from the controls (p = 0.01) and the benznidazole‐treated mice (p = 0.03), while this was not the case at 85 days post‐treatment. These results are encouraging for continuing the investigation of other analogues of 2‐n‐propylquinoline in experimental chronic Chagas' disease. Copyright © 2001 John Wiley & Sons, Ltd.