Phosphoinositide kinases
- 1 April 1996
- journal article
- review article
- Published by Elsevier BV in Current Opinion in Cell Biology
- Vol. 8 (2), 153-158
- https://doi.org/10.1016/s0955-0674(96)80060-3
Abstract
Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has identified a number of processes in which phosphoinositide 3-kinase participates, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. Several possible biochemical targets of phosphoinositides have been found.Keywords
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