Supplementary Figures 1 - 5, Table 1 from Inhibition of Wee1, AKT, and CDK4 Underlies the Efficacy of the HSP90 Inhibitor XL888 in an In Vivo Model of NRAS-Mutant Melanoma

Abstract

PDF file - 295K, Supplemental Figure 1: XL888 (0.3 μM) treatment induces the nuclear accumulation of FOXO3a. Supplemental Figure 2: XL888 decreases Mcl-1 mRNA expression in NRAS mutant melanoma. Supplemental Figure 3: BAK is not required for XL888-mediated apoptosis. Supplemental Figure 4: The BH3 family protein inhibitor ABT-737 enhances the pro-apoptotic effects of XL888 in the WM1366 and WM1361A cell lines. Supplemental Figure 5: The effects of XL888 (300nM) and ABT-737 (1 μM) on the viability of NRAS mutant melanoma spheroids. Supplemental Table 1: List of heat shock proteins used on the LC-MRM by UniPROT ID and gene name.