Plethysmography and impulse oscillometry assessment of tiotropium and ipratropium bromide; a randomized, double-blind, placebo-controlled, cross-over study in healthy subjects
Open Access
- 14 February 2006
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 61 (4), 398-404
- https://doi.org/10.1111/j.1365-2125.2006.02594.x
Abstract
Aims Spirometry, plethysmography and impulse oscillometry (IOS) measure different aspects of lung function. These methods have not been compared for their ability to assess long‐ and short‐acting anticholinergic agents. We therefore performed a double‐blind, placebo‐controlled, four‐way cross‐over study in 30 healthy subjects. Methods Single doses of tiotropium bromide (Tio) 54 and 18 mcg, ipratropium bromide (IB) 40 mcg and placebo were administered. Specific conductance (sGaw), total lung capacity (TLC), inspiratory capacity (IC) and residual volume (RV) were measured using plethysmography, while IOS measured resistance (R5–25) and reactance (RF and X5). Pulmonary function was measured for 26 h post dose. Results Tio caused significant improvements in sGaw, forced expiratory voume in 1 s (FEV1), maximum mid‐expiratory flow (MMEF) and R5–R25 at time points up to 26 h, with no clear differences between doses. IB improved the same parameters, but only up to 8 h. The weighted mean change (0–24 h) caused by Tio 54 mcg compared with placebo for FEV1 was 240 ml (95% confidence interval 180, 300), while for sGaw the ratio of geometric means (Tio compared with placebo) was 1.35 (1.28, 1.41). Neither drug caused consistent statistically significant changes in RF, forced vital capacity, TLC or IC over 26 h. RV was significantly improved from 8 to 24 h by Tio 54 mcg only. Conclusions In addition to spirometry, IOS resistance measurements and sGaw can distinguish between the effects of long‐ and shortacting anticholinergic effects in healthy subjects.Keywords
This publication has 11 references indexed in Scilit:
- Clinical applications of forced oscillation to assess peripheral airway functionRespiratory Physiology & Neurobiology, 2005
- Measuring bronchodilation in COPD clinical trialsBritish Journal of Clinical Pharmacology, 2005
- The role of anticholinergics in chronic obstructive pulmonary diseaseThe American Journal of Medicine Supplements, 2004
- Tiotropium BromideChest, 2004
- A comparison of lung function methods for assessing dose–response effects of salbutamolBritish Journal of Clinical Pharmacology, 2004
- Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPDEuropean Respiratory Journal, 2004
- Improvement in Resting Inspiratory Capacity and Hyperinflation With Tiotropium in COPD Patients With Increased Static Lung Volumes *Chest, 2003
- Prolonged effect of tiotropium bromide on methacholine-induced bronchoconstriction in asthma.American Journal of Respiratory and Critical Care Medicine, 1996
- Tiotropium bromide, a new long-acting antimuscarinic bronchodilator: a pharmacodynamic study in patients with chronic obstructive pulmonary disease (COPD). Dutch Study GroupEuropean Respiratory Journal, 1995
- Ba 679 BR, A novel long-acting anticholinergic bronchodilatorLife Sciences, 1993