Terpenoids as potential chemopreventive and therapeutic agents in liver cancer
Open Access
- 1 January 2011
- journal article
- review article
- Published by Baishideng Publishing Group Inc. in World Journal of Hepatology
- Vol. 3 (9), 228-249
- https://doi.org/10.4254/wjh.v3.i9.228
Abstract
Despite significant advances in medicine, liver cancer, predominantly hepatocellular carcinoma remains a major cause of death in the United States as well as the rest of the world. As limited treatment options are currently available to patients with liver cancer, novel preventive control and effective therapeutic approaches are considered to be reasonable and decisive measures to combat this disease. Several naturally occurring dietary and non-dietary phytochemicals have shown enormous potential in the prevention and treatment of several cancers, especially those of the gastrointestinal tract. Terpenoids, the largest group of phytochemicals, traditionally used for medicinal purposes in India and China, are currently being explored as anticancer agents in clinical trials. Terpenoids (also called "isoprenoids") are secondary metabolites occurring in most organisms, particularly plants. More than 40 000 individual terpenoids are known to exist in nature with new compounds being discovered every year. A large number of terpenoids exhibit cytotoxicity against a variety of tumor cells and cancer preventive as well as anticancer efficacy in preclinical animal models. This review critically examines the potential role of naturally occurring terpenoids, from diverse origins, in the chemoprevention and treatment of liver tumors. Both in vitro and in vivo effects of these agents and related cellular and molecular mechanisms are highlighted. Potential challenges and future directions involved in the advancement of these promising natural compounds in the chemoprevention and therapy of human liver cancer are also discussed. (C) 2011 Baishideng. All rights reserved.Keywords
This publication has 179 references indexed in Scilit:
- Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis‐promoted hepatocarcinogenesis in ratsInternational Journal of Cancer, 2009
- Epigallocatechin 3-Gallate and Green Tea Catechins: United They Work, Divided They FailCancer Prevention Research, 2009
- Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3′,4,4′-tetrachlorobiphenyl (PCB-77)Food and Chemical Toxicology, 2008
- Sorafenib in Advanced Hepatocellular CarcinomaThe New England Journal of Medicine, 2008
- The role of herbs and spices in cancer preventionThe Journal of Nutritional Biochemistry, 2008
- Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancerNature Reviews Cancer, 2007
- Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratioCancer Cell International, 2007
- Ganoderiol F, a ganoderma triterpene, induces senescence in hepatoma HepG2 cellsLife Sciences, 2006
- Molecular mechanisms of echinocystic acid-induced apoptosis in HepG2 cellsBiochemical and Biophysical Research Communications, 2004
- No evidence for an inhibitory effect of β‐carotene or of canthaxanthin on the initiation of liver preneoplastic foci by diethylnitrosamine in the ratNutrition and Cancer, 1996