Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors
Open Access
- 1 November 2016
- journal article
- research article
- Published by Elsevier BV in Cell Reports
- Vol. 17 (6), 1560-1570
- https://doi.org/10.1016/j.celrep.2016.10.017
Abstract
No abstract availableKeywords
Funding Information
- NIH (R01 AI104384, R01 AI081625)
This publication has 48 references indexed in Scilit:
- Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcodingScientific Reports, 2014
- Developmental pathway for potent V1V2-directed HIV-neutralizing antibodiesNature, 2014
- Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infectionAIDS, 2014
- Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 NeutralizationCell, 2013
- Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell OntogeniesImmunity, 2012
- Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding SiteJournal of Virology, 2012
- Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational DesignScience, 2011
- The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4 + T Cell Decline and High Viral Load during Acute InfectionJournal of Virology, 2011
- Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1Science, 2010
- Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120Science, 2009