Aging and Sleep: Physiology and Pathophysiology
- 12 October 2010
- journal article
- review article
- Published by Georg Thieme Verlag KG in Seminars in Respiratory and Critical Care Medicine
- Vol. 31 (05), 618-633
- https://doi.org/10.1055/s-0030-1265902
Abstract
Aging effects on sleep are important to consider for the practicing pulmonologist due to the increase in prevalence of major respiratory disorders as well as the normal changes that occur in sleep patterns with aging. Typically, aging is associated with decreases in the amount of slow wave sleep and increases in stage 1 and 2 non–rapid eye movement sleep, often attributed to an increased number of spontaneous arousals that occur in the elderly. Elderly individuals tend to go to sleep earlier in the evening and wake earlier due to a phase advance in their normal circadian sleep cycle. Furthermore the development of sleep-related respiratory disorders such as obstructive sleep apnea (OSA) and central sleep apnea or Cheyne-Stokes respiration (CSA-CSR) associated with congestive heart failure (CHF) occur with increasing prevalence in the elderly. The development of such disorders is often of major concern because they are associated with systemic hypertension and cardiovascular disease, metabolic disorders such as diabetes, and impaired neurocognition. The present review reflects the current understanding of the normal changes in sleep patterns and sleep needs with advancing age, in addition to the effect that aging has on the predisposition to and consequences of OSA and CSA-CSR associated with CHF.Keywords
This publication has 100 references indexed in Scilit:
- The effects of normal aging on sleep spindle and K-complex productionClinical Neurophysiology, 2002
- A Mechanism of Central Sleep Apnea in Patients with Heart FailureThe New England Journal of Medicine, 1999
- Relationship between body mass index, age and upper airway measurements in snorers and sleep apnoea patientsEuropean Respiratory Journal, 1996
- Effect of Theophylline on Sleep-Disordered Breathing in Heart FailureThe New England Journal of Medicine, 1996
- Hypersomnolence and neurocognitive performance in sleep apnea. Editorial reviewCurrent Opinion in Pulmonary Medicine, 1995
- Aging and changes in phasic events during sleepPhysiology & Behavior, 1993
- Blood pressure, systolic and diastolic, and cardiovascular risks. US population dataArchives of Internal Medicine, 1993
- Pharyngeal Size in Snorers, Nonsnorers, and Patients with Obstructive Sleep ApneaThe New England Journal of Medicine, 1986
- The clinical pathology of heart failure and atrial fibrillation in old ageHeart, 1979
- Changes in sleep cycle patterns with ageJournal of Psychiatric Research, 1974