Two‐stage meta‐analysis of survival data from individual participants using percentile ratios
Open Access
- 24 July 2012
- journal article
- conference paper
- Published by Wiley in Statistics in Medicine
- Vol. 31 (30), 4296-4308
- https://doi.org/10.1002/sim.5516
Abstract
Methods for individual participant data meta‐analysis of survival outcomes commonly focus on the hazard ratio as a measure of treatment effect. Recently, Siannis et al. (2010, Statistics in Medicine 29:3030–3045) proposed the use of percentile ratios as an alternative to hazard ratios. We describe a novel two‐stage method for the meta‐analysis of percentile ratios that avoids distributional assumptions at the study level. Copyright © 2012 John Wiley & Sons, Ltd.Keywords
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