Unilateral Hemispheric Memory and Hippocampal Neuronal Density in Temporal Lobe Epilepsy
- 1 April 1993
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurosurgery
- Vol. 32 (4), 574-581
- https://doi.org/10.1227/00006123-199304000-00013
Abstract
WE EXAMINED THE relationship of preoperative unilateral memory function and quantitative hippocampal histology in patients undergoing anterior temporal lobectomy for the treatment of complex partial seizures. Recognition memory (objects, words, figures) was assessed preoperatively for each hemisphere by the intracarotid amobarbital procedure in 23 patients (mean age at the time of operation, 30.2 yr; standard deviation, 9.2; mean age at the time of seizure onset, 12.3 yr; standard deviation, 8.6) without tumor. Memory scores were the total number of items recognized, adjusted for guessing. Histological examination of the anterior 20 to 30 mm of hippocampal tissue was accomplished in all patients. The degree of unilateral memory impairment ipsilateral to the seizure focus was significantly correlated with decreased neuronal density in the hilar (r = 0.66, P < 0.001) and dentate granule (r = 0.61, P < 0.002) regions, but not in the CA1 (r = 0.10, P = not significant) or CA2-3 (r = 0.35, P = not significant) regions. Memory performance with the contralateral hemisphere was not significantly correlated with ipsilateral hippocampal densities. These data support the role of the hippocampus in human memory and show further evidence of hippocampal subfield specificity in the relationship between memory performance and neuronal cell loss. Further studies of the dentate granule and hilar regions in relation to human memory are warranted.Keywords
This publication has 35 references indexed in Scilit:
- Hippocampal neuronal density in temporal lobe epilepsy with and without gliomasActa Neuropathologica, 1990
- Alzheimer's disease: Glutamate depletion in the hippocampal perforant pathway zoneAnnals of Neurology, 1987
- Reference and working memory of rats following hippocampal damage induced by transient forebrain ischemiaPhysiology & Behavior, 1986
- Bilateral and limited amygdalohippocampal lesions causing a pure amnesic syndromeAnnals of Neurology, 1985
- Temporal Lobe Volumetric Cell Densities in Temporal Lobe EpilepsyEpilepsia, 1984
- Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal FormationScience, 1984
- Amnesia with hippocampal lesions cardiopulmonary arrestNeurology, 1984
- Memory Function in Focal Epilepsy: A Comparison of Non-Surgical, Unilateral Temporal Lobe and Frontal Lobe SamplesCortex, 1980
- Right Temporal-Lobe DamageArchives of Neurology, 1963
- Estimation of nuclear population from microtome sectionsThe Anatomical Record, 1946