Expression of chemokine receptors in the different clinical forms of multiple sclerosis
- 1 October 2002
- journal article
- research article
- Published by SAGE Publications in Multiple Sclerosis Journal
- Vol. 8 (5), 390-395
- https://doi.org/10.1191/1352458502ms841oa
Abstract
Chemokines and their receptors are important in the trafficking of peripheral leukocytes into the central nervous system, a major event in the pathogenesis of multiple sclerosis (MS). Evidence based on clinical, pathological and magnetic resonance imaging grounds supports some divergence between forms of MS with relapses [relapsing-remitting (RR) and secondary progressive (SP)] and the primary progressive (PP) form. To elucidate whether different pathogenic mechanisms are involved in PPMS, we compared membrane expression of a group of CC and CXC chemokine receptors (CCR1, CCR5, CXCR3, CXCR4) in peripheral blood of 68 MS patients (25 PPMS, 23 SPMS and 20 RRMS) and 26 healthy controls. We found a significant increase in surface expression of CCR5 in CD4+, CD8+, CD19+ and CD14+ cells as well as an increased percentage of CXCR3 and CXCR4 in CD14+ cells in MS patients compared to controls. Increased levels of CXCL10 (IP-10) and CCL5 (RANTES) in cerebrospinal fluid were also observed in a subgroup of MS patients. These results support that chemokines and their receptors are involved in the pathogenesis of MS. However, a pattern of chemokine-chemokine receptor expression characteristic of each clinical form of the disease failed to be observed.Keywords
This publication has 21 references indexed in Scilit:
- Expression of the interferon‐γ‐inducible chemokines IP‐10 and Mig and their receptor, CXCR3, in multiple sclerosis lesionsNeuropathology and Applied Neurobiology, 2000
- Increased numbers of CCR5+ interferon-?- and tumor necrosis factor-?-secreting T lymphocytes in multiple sclerosis patientsAnnals of Neurology, 2000
- Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patientsJCI Insight, 1999
- Expression of monocyte chemoattractant protein-1 and other β-chemokines by resident glia and inflammatory cells in multiple sclerosis lesionsJournal of Neuroimmunology, 1998
- Chemokines and leukocyte trafficNature, 1998
- Primary progressive multiple sclerosisBrain, 1997
- Lymphocyte Homing and HomeostasisScience, 1996
- Circulating adhesion molecules and tumor necrosis factor receptor in multiple sclerosis: Correlation with magnetic resonance imagingAnnals of Neurology, 1995
- Macrophage inflammatory protein-1α in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological diseasesJournal of the Neurological Sciences, 1995
- Patterns of disease activity in multiple sclerosis: clinical and magnetic resonance imaging study.BMJ, 1990